When I play two-hand Fluxx, which I do the most often since I only have one other person with whom to play, if the card played isn't practicable, like Reverse Order, we ignore it, or I try to remember to pull it from the deck before we play, like pulling the Borders Bonus card when I play in a private home.
The whole point of Fluxx is the changeable rules. When I got my
Christmas bonus pack this year there was a Goal card that involved
Keepers I didn't have, so I used my Fluxx Blanxx to create the
appropriate Keepers, then created several new Goal cards to use the
new Keepers. [BTW, my favorite new Goal is called "Calorie Free." It
requires the Gift (one of the Keepers I had to make) and Chocolate
(one of the traditional) Keepers, since candy received as a gift has
no calories. You are welcome to borrow this Goal for your game if you
have or make the Gift Keeper.
Elise Dee Beraru