I have a few favourite cards, but I really like Go Fish. It's a little confusing to new players because they don't know what the names of the cards are but I remember using it to good effect the first day i was introduced to Fluxx. I find it quite satisfying to Go Fish for a goal and force someone to hand it over for the win. There is also something about fishing for a keeper, and finding as the top card of the deck. As for least favourite, it used to be hand limit 0, but lately i've changed that opinion. In my current Fluxx group if someone has hand limit 0 in their opening hand it usually is their first play (with some exceptions). There are a lot of cards that are frustrating when used against you, but they are even more fun to use against someone else. At the moment i don't play with the Computer keeper in the deck, because i feel that it is unbalanced and i haven't found a good method to balance it yet. First play random is another one that i dislike, but only because it's so easy to forget to do, not because of what it does to the gameplay. Blessings, Darren